Background: Thyroid alterations have adverse effects on other health systems\nin the body, and reproductive system is one of the most affected organs. Here,\nwe perform a comprehensive analysis on the effects of different thyroid abnormalities\non sexual and reproductive-related hormones in both men and\nwomen in different age groups. Method: A comprehensive analysis was performed\non 15,043 subjects within the reproductive age (15 - 49 years). They\nwere tested for thyroid markers (TSH, FT4, anti-TPO, anti-Tg) and 13 reproductive\nhormones in Vibrant America Clinical Laboratory between March\n2016 to July 2018. The alterations of each reproductive hormone in hypothyroidism,\nhyperthyroidism, anti-TPO+ anti-Tg+ groups were evaluated. Results:\nA total of 10,626 women was tested. Women with hypothyroidism had\nelevated cortisol and low SHBG and DHEA-S. Women with hyperthyroidism\nshowed elevated total testosterone and SHBG. Women seropositive for anti-\nTPO had elevated total testosterone and low cortisol. Women seropositive\nfor anti-Tg had low parathyroid hormones. Similarly, a total of 4417 men was\ntested. Men with hypothyroidism had low IGF-I. Similarly, men with hyperthyroidism\nhad low DHEA-S, but elevated estradiol, FSH, LH and prolactin.\nMen seropositive for anti-TPO had elevated SHBG and low progesterone.\nMen seropositive for anti-Tg had elevated progesterone. The reproductive\nand related hormone levels of age group 36 - 49 showed the most variations.\nConclusion: Our results clearly show that individuals with different thyroid\nalterations have different effects on reproductive health, especially in the age\ngroup 36 - 49. Hence, routine testing and follow-up checkups on reproductive\nsystem would be beneficial for individuals in the age group 36 - 49 with thyroid\ndisorders.
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